This seminar addresses the philosophical problems arising from the portrayal of mankind which, as a result of various scientific developments and insights, is increasingly naturalized. The research questions address the issue of meaning and purpose, freedom, autonomy and responsibility, and of existential attitudes towards finiteness. Examples are: How to engage in search for meaning without a frame of reference that is external to man? How to develop ethics if human behaviour is completely causally determined? What is the value of subjective experiences if these can be entirely reduced to brain processes? How do we deal with human suffering and death without adding a deeper meaning or significance?